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Occasionally, a genetic error occurs during egg or sperm cell formation.

A child conceived with such an egg or sperm cell may inherit an incorrect number of chromosomes.

The baby may also have a cleft lip or cleft palate .

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The head is unusually small and the back of the head is prominent.

The ears are malformed and low-set, and the mouth and jaw are small (micrognathia).

It causes major physical abnormalities and severe mental retardation .

Very few children afflicted with this syndrome survive beyond the first year.

The child may have an umbilical or inguinal hernia , malformed kidneys, and abnormalities of the urogenital system, including undescended testicles in a male child (cryptochordism).

A child with Edwards' syndrome is likely to have many medical and development needs.Edwards' syndrome is associated with the presence of a third copy of chromosome number 18. Chromosomes are numbered 1–22, and the 23rd pair is composed of the sex chromosomes, X and Y.A person inherits one set of 23 chromosomes from each parent.It is the second most common trisomy, after trisomy 21 ( Down syndrome ).Edwards' syndrome occurs in approximately one in every 5,000 live births and one in every 5,000 stillborn births; it affects girls more often than boys.Women older than their early thirties have a greater risk of conceiving a child with Edwards' syndrome, but it can also occur with younger mothers.

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