Cystic fibrosis dating cystic fibrosis patients männer suchen männer kostenlos Bremerhaven

A person’s specific combination of mutations affects both the severity of the disease and how well the patient responds to treatment.Recent years have brought hope in the form of several drugs known as CFTR modulators that counteract the effects of mutations in certain cystic fibrosis-linked genes.While the new drugs are life-changing for some patients, they do not work for everyone.

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People develop CF because they do not have a functioning version of the CFTR gene.

But the condition, which involves the buildup of thick, sticky mucus in the lungs, is tied to more than 2,000 genetic mutations.

Guimbellot and Gentzsch learned how to grow nasospheroids from cells taken from the inside of the noses of cystic fibrosis patients.

The researchers then exposed the nasospheroids to various CFTR drugs to see what would happen.

“When CFTR is turned on, the balls shrink down—mediated by the transport of salt and water—and we can quantify that by measuring the size of the balls,” says Guimbellot.

The results suggest growing nasospheroids from nasal samples could provide a quick screening method to determine how a patient’s cells react to different CFTR drugs.

A trial-and-error approach for each patient—simply giving each available drug to every patient—is not feasible because the drugs cost hundreds of thousands of dollars, can take several months to work, and come with a risk of side effects.

Currently, the only test available to predict how a patient will respond to CFTR drugs requires a rectal biopsy, followed by complicated laboratory manipulation of the sample to determine the drug’s likely effectiveness. She was working with lead study author Martina Gentzsch, associate professor of cell biology and physiology at the University of North Carolina, on an unrelated research project when she noticed some funny little balls forming from cells taken from the inside of the nose.

It might even be more reliable from a screening standpoint because the drugs are able to interact directly with the right parts on the outside of the nasospheroids, rather than having to enter the spheroids as required with the rectal biopsy method.

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